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Genetic Predictors of Ibrutinib-Related Cardiovascular Side Effects in Patients with Chronic Lymphocytic Leukemia
CONCLUSIONS: Our findings suggest possible genetic determinants of ibrutinib-related CVSEs in CLL. If replicated in a larger study, pre-treatment pharmacogenetic testing for GATA4 and KCNQ1 polymorphisms may be a useful clinical tool for personalizing treatment selection for CLL and/or instituting early risk-mitigation strategies.PMID:37738027 | DOI:10.1158/1078-0432.CCR-23-0421
Source: Clinical Cancer Research - September 22, 2023 Category: Cancer & Oncology Authors: Issam S Hamadeh Jai N Patel Ryan Jacobs Hang Zeng Jiaxian He Bei Hu Tamara Kay Moyo Amy Soni Steven Park Ed Copelan Belinda Avalos Alicia Hamilton Nury Steuerwald Nilanjan Ghosh Source Type: research
Non-coding RNAs in cancer immunotherapy: Predictive biomarkers and targets
CONCLUSION: This review summarises important predictive ncRNA biomarkers that were reported in cancer patients treated with different immunotherapeutic modalities, including monoclonal antibodies, small molecule inhibitors, cancer vaccines and CAR-T cells. In addition, a concise discussion on forthcoming perspectives is provided, outlining technical approaches for the optimal utilisation of immunomodulatory ncRNA biomarkers as predictive tools and therapeutic targets.PMID:37735815 | DOI:10.1002/ctm2.1425
Source: Clinical Lung Cancer - September 22, 2023 Category: Cancer & Oncology Authors: Murad Alahdal Eyad Elkord Source Type: research
Methiothepin downregulates SNAP-23 and inhibits degranulation of rat basophilic leukemia cells and mouse bone marrow-derived mast cells
This article is protected by copyright. All rights reserved.PMID:37736882 | DOI:10.1002/eji.202250360
Source: European Journal of Immunology - September 22, 2023 Category: Allergy & Immunology Authors: Daisuke Kondo Ruriko Suzuki Ayako Matsumura Hitomi Meguri Masahiko Tanaka Makoto Itakura Naohide Hirashima Source Type: research
Therapeutic benefits of prophetic medicine remedies in treating hematological diseases (A review article)
Am J Blood Res. 2023 Aug 15;13(4):130-142. eCollection 2023.ABSTRACTHematological disorders are common medical ailments constituting an important cause of morbidity and mortality worldwide, which may be managed efficiently using different prophetic medicine remedies as adjuvants to current therapeutics. Prophetic medicine includes the body of knowledge about medicine that has been derived from the deeds, customs (sunnah), ahadith (sayings), actions, and agreements of Prophet Muhammad, peace be upon him. This review article aims at exploring the magnitude of therapeutic benefits of prophetic medicine remedies as adjuvant tr...
Source: Cell Research - September 22, 2023 Category: Cytology Authors: Ghazi H Mogharbel Ahmad S Badawi Amal Yaseen Zaman Mehrevan M Abd Elmoniem Ibrahim M Abdel-Rahman Mariam Eid Alenazi Fareed Akbar Shah Mohamed Abdelnaem Aly Syed Nazar Imam Nusaybah Eid Alenazi Salah Mohamed El Sayed Source Type: research
Pharmacological inhibition of the MLL1-menin-interaction aggravates acute kidney injury induced by folic acid and ischemia/reperfusion in mice
In this study, we investigated the role and mechanisms of MLL1 in murine models of acute kidney injury (AKI) induced by folic acid (FA) and ischemia/reperfusion (I/R). Injury to the kidney elevated expression of MLL1, Menin, WDR5 and H3K4Me3, which was accompanied by increased serum creatinine (Scr) and blood urea nitrogen (BUN), renal tubular injury and apoptosis. Pharmacological inhibition of MLL1 activity with MI503 to disrupt the interaction between MLL1 with Menin further increased Scr and BUN levels, enhanced expression of neutrophil gelatinase associated lipocalin and kidney injury molecule-1, and induced more apopt...
Source: American Journal of Physiology. Renal Physiology - September 21, 2023 Category: Physiology Authors: Xiying Hou Binbin Cui Andong Qiu Na Liu Shougang Zhuang Source Type: research
Design and synthesis of novel 1,2,3,4-tetrazines as new anti-leukemia cancer agents
Chem Biol Drug Des. 2023 Sep 20. doi: 10.1111/cbdd.14328. Online ahead of print.ABSTRACTA series of novel 1,2,3,4-tetrazines were designed and synthesized. 1 H-NMR spectroscopy, 13 C NMR spectroscopy, and HRMS were used to determine the structures of this novel compounds. Computational approaches suggested that DHFR is a putative target for the newly synthesized 11 compounds. Extensive molecular dynamics simulations followed by molecular docking simulations were employed to evaluate DHFR as a potential target protein. The anticancer activities of the compounds were evaluated against five different types of leukemia cell li...
Source: Cancer Control - September 21, 2023 Category: Cancer & Oncology Authors: Oznur Eyilcim Fulya Gunay Omer Tahir Gunkara Yuk Yin Ng Ozlem Ulucan Ihsan Erden Source Type: research
Prehistory of chronic lymphocytic leukemia: clues from the B-cell receptor
Haematologica. 2023 Sep 21. doi: 10.3324/haematol.2023.283799. Online ahead of print.ABSTRACTNot available.PMID:37731392 | DOI:10.3324/haematol.2023.283799
Source: Haematologica - September 21, 2023 Category: Hematology Authors: Frederic Davi Source Type: research
Immune checkpoint molecule DNAM-1/CD112 axis is a novel target for NK-cell therapy in acute myeloid leukemia
In conclusion, the modification of the DNAM-1/CD112 axis in NK cells may be an effective novel immunotherapy for AML. Furthermore, these results suggest the potential of the expression levels of these molecules as prognostic markers in AML.PMID:37731380 | DOI:10.3324/haematol.2023.282915
Source: Haematologica - September 21, 2023 Category: Hematology Authors: Yuta Kaito Emi Sugimoto Fumi Nakamura Yutaka Tsukune Makoto Sasaki Shunsuke Yui Hiroki Yamaguchi Susumu Goyama Yasuhito Nannya Kinuko Mitani Hideto Tamura Yoichi Imai Source Type: research
Physiologically Based Pharmacokinetic Modeling of the Drug-Drug Interaction Between CYP3A4 Substrate Glasdegib and Moderate CYP3A4 Inducers in Lieu of a Clinical Study
This article is protected by copyright. All rights reserved.PMID:37731282 | DOI:10.1002/jcph.2348
Source: The Journal of Clinical Pharmacology - September 21, 2023 Category: Drugs & Pharmacology Authors: Ernesto Callegari Susanna Tse Angela C Doran Theunis C Goosen Naveed Shaik Source Type: research
Exosomal circKIAA1797 Regulates Cell Progression and Glycolysis by Targeting miR-4429/PBX3 Pathway in Gastric Cancer
Biochem Genet. 2023 Sep 20. doi: 10.1007/s10528-023-10529-z. Online ahead of print.ABSTRACTIn recent years, circular RNAs (circRNAs) are extensively studied in the progression of various types of cancer, while the mechanism of circKIAA1797 is rarely studied in gastric cancer (GC). Hence, this research aimed to investigate the expression of exosomal circKIAA1797 and its biological function in GC cells. Exosomes were extracted from the serum of GC patients and identified by transmission electron microscopy (TEM) and nanoparticle tracking analyzer (NTA). CD81, CD63, Bcl-2, Bax, and pre-leukemia transcription factor 3 (PBX3) p...
Source: Biochemical Genetics - September 21, 2023 Category: Genetics & Stem Cells Authors: Xiaomei Zheng Hongwei Xiao Xiaoxiao Liu Ting Huang Chengwei Deng Source Type: research
Physiologically Based Pharmacokinetic Modeling of the Drug-Drug Interaction Between CYP3A4 Substrate Glasdegib and Moderate CYP3A4 Inducers in Lieu of a Clinical Study
This article is protected by copyright. All rights reserved.PMID:37731282 | DOI:10.1002/jcph.2348
Source: The Journal of Clinical Pharmacology - September 21, 2023 Category: Drugs & Pharmacology Authors: Ernesto Callegari Susanna Tse Angela C Doran Theunis C Goosen Naveed Shaik Source Type: research
Pediatric acute myeloid leukemia and hyperleukocytosis with WBC count greater than 50 × 10 < sup > 9 < /sup > /L
CONCLUSIONS: Pediatric AML patients with hyperleukocytosis have the similar prognosis regardless of whether their WBC count is 50-100 × 109/L or ≥ 100 × 109/L.PMID:37733171 | DOI:10.1007/s12185-023-03665-0
Source: International Journal of Hematology - September 21, 2023 Category: Hematology Authors: Aoli Zhang Lipeng Liu Suyu Zong Lixian Chang Xiaojuan Chen Wenyu Yang Ye Guo Li Zhang Yao Zou Yumei Chen Yingchi Zhang Min Ruan Xiaofan Zhu Source Type: research
Pharmacological inhibition of the MLL1-menin-interaction aggravates acute kidney injury induced by folic acid and ischemia/reperfusion in mice
In this study, we investigated the role and mechanisms of MLL1 in murine models of acute kidney injury (AKI) induced by folic acid (FA) and ischemia/reperfusion (I/R). Injury to the kidney elevated expression of MLL1, Menin, WDR5 and H3K4Me3, which was accompanied by increased serum creatinine (Scr) and blood urea nitrogen (BUN), renal tubular injury and apoptosis. Pharmacological inhibition of MLL1 activity with MI503 to disrupt the interaction between MLL1 with Menin further increased Scr and BUN levels, enhanced expression of neutrophil gelatinase associated lipocalin and kidney injury molecule-1, and induced more apopt...
Source: Am J Physiol Renal P... - September 21, 2023 Category: Urology & Nephrology Authors: Xiying Hou Binbin Cui Andong Qiu Na Liu Shougang Zhuang Source Type: research
Single-cell genotypic and phenotypic analysis of measurable residual disease in acute myeloid leukemia
Sci Adv. 2023 Sep 22;9(38):eadg0488. doi: 10.1126/sciadv.adg0488. Epub 2023 Sep 20.ABSTRACTMeasurable residual disease (MRD), defined as the population of cancer cells that persist following therapy, serves as the critical reservoir for disease relapse in acute myeloid leukemia and other malignancies. Understanding the biology enabling MRD clones to resist therapy is necessary to guide the development of more effective curative treatments. Discriminating between residual leukemic clones, preleukemic clones, and normal precursors remains a challenge with current MRD tools. Here, we developed a single-cell MRD (scMRD) assay ...
Source: Adv Data - September 20, 2023 Category: Epidemiology Authors: Troy M Robinson Robert L Bowman Sonali Persaud Ying Liu Rosemary Neigenfind Qi Gao Jingping Zhang Xiaotian Sun Linde A Miles Sheng F Cai Adam Sciambi Aaron Llanso Christopher Famulare Aaron Goldberg Ahmet Dogan Mikhail Roshal Ross L Levine Wenbin Xiao Source Type: research
